Crossley Lab
member portrait Professor Merlin Crossley Group Leader and Deputy Vice Chancellor Academic Quality (UNSW Sydney)
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Professor Merlin Crossley has experience leading both Education and Research portfolios, and has served as Dean of Science and in several DVC roles at UNSW. He is also a Pro-Chancellor of the university and contributes at graduations.

He is an enthusiastic science communicator, Chair of the Editorial Board of The Conversation, of UNSW Press, Deputy Director of the Australian Science Media Centre, a member of the Editorial Board of BioEssays, and an Honorary Associate of the Australian Museum.

His lab works on CRISPR gene editing to treat inherited blood disorders. He has been recognized by multiple awards, including a Rhodes Scholarship, the 2020 NSW Premier’s Award for Medical Biological Science, the 2021 Lemberg Medal from the Australian Society for Biochemistry and Molecular Biology.

In 2021 a new species of iridescent butterfly bobtail squid was named in his honour – Iridoteuthis merlini – Merlin’s bobtail squid.

Merlin’s Publications

2022

Effective therapies for sickle cell disease: are we there yet?
Effective therapies for sickle cell disease: are we there yet?
Merlin Crossley, Georgios E. Christakopoulos, Mitchell J. Weiss
Trends in Genetics  ·  01 Dec 2022  ·  doi:10.1016/j.tig.2022.07.003
Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression
Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression
Sarah K. Topfer, Ruopeng Feng, Peng Huang, Lana C. Ly, Gabriella E. Martyn, Gerd A. Blobel, Mitchell J. Weiss, Kate G. R. Quinlan, Merlin Crossley
Blood  ·  07 Apr 2022  ·  doi:10.1182/blood.2021014205

2021

Structural basis for human ZBTB7A action at the fetal globin promoter
Structural basis for human ZBTB7A action at the fetal globin promoter
Yang Yang, Ren Ren, Lana C. Ly, John R. Horton, Fudong Li, Kate G.R. Quinlan, Merlin Crossley, Yunyu Shi, Xiaodong Cheng
Cell Reports  ·  01 Sep 2021  ·  doi:10.1016/j.celrep.2021.109759
ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression
ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression
Xianjiang Lan, Ren Ren, Ruopeng Feng, Lana C. Ly, Yemin Lan, …, Merlin Crossley, Mitchell J. Weiss, Xiaodong Cheng, Junwei Shi, Gerd A. Blobel
Molecular Cell  ·  01 Jan 2021  ·  doi:10.1016/j.molcel.2020.11.006

2020

Global citizen deliberation on genome editing
Global citizen deliberation on genome editing
John S. Dryzek, Dianne Nicol, Simon Niemeyer, Sonya Pemberton, Nicole Curato, …, Jennifer Merchant, Anna Middleton, John E. J. Rasko, Ine Van Hoyweghen, Antoine Vergne
Science  ·  18 Sep 2020  ·  doi:10.1126/SCIENCE.ABB5931
Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)
Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)
Alexander J. Knights, Emily J. Vohralik, Peter J. Houweling, Elizabeth S. Stout, Laura J. Norton, …, Kim S. Bell-Anderson, Kathryn N. North, Kyle L. Hoehn, Merlin Crossley, Kate G. R. Quinlan
Nature Communications  ·  10 Jun 2020  ·  doi:10.1038/s41467-020-16758-9
Methylation of a CGATA element inhibits binding and regulation by GATA-1
Methylation of a CGATA element inhibits binding and regulation by GATA-1
Lu Yang, Zhiliang Chen, Elizabeth S. Stout, Fabien Delerue, Lars M. Ittner, Marc R. Wilkins, Kate G. R. Quinlan, Merlin Crossley
Nature Communications  ·  22 May 2020  ·  doi:10.1038/s41467-020-16388-1
Krüppel-like factor 3 (KLF3) suppresses NF-κB–driven inflammation in mice
Krüppel-like factor 3 (KLF3) suppresses NF-κB–driven inflammation in mice
Alexander J. Knights, Lu Yang, Manan Shah, Laura J. Norton, Gamran S. Green, Elizabeth S. Stout, Emily J. Vohralik, Merlin Crossley, Kate G.R. Quinlan
Journal of Biological Chemistry  ·  01 May 2020  ·  doi:10.1074/jbc.RA120.013114

2019

Hit and Run Transcriptional Repressors Are Difficult to Catch in the Act
Hit and Run Transcriptional Repressors Are Difficult to Catch in the Act
Manan Shah, Alister P. W. Funnell, Kate G. R. Quinlan, Merlin Crossley
BioEssays  ·  27 Jun 2019  ·  doi:10.1002/bies.201900041
A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site
A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site
Gabriella E. Martyn, Beeke Wienert, Ryo Kurita, Yukio Nakamura, Kate G. R. Quinlan, Merlin Crossley
Blood  ·  21 Feb 2019  ·  doi:10.1182/blood-2018-07-863951

2018

Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies
Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies
Beeke Wienert, Gabriella E. Martyn, Alister P.W. Funnell, Kate G.R. Quinlan, Merlin Crossley
Trends in Genetics  ·  01 Dec 2018  ·  doi:10.1016/j.tig.2018.09.004
Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules
Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules
Crisbel M. Artuz, Alexander J. Knights, Alister P.W. Funnell, Thomas J. Gonda, Katya Ravid, Richard C.M. Pearson, Kate G.R. Quinlan, Merlin Crossley
Biotechnology Reports  ·  01 Dec 2018  ·  doi:10.1016/j.btre.2018.e00285
Charting a noncoding gene for γ-globin activation
Charting a noncoding gene for γ-globin activation
Gerd A. Blobel, Merlin Crossley
Blood  ·  01 Nov 2018  ·  doi:10.1182/blood-2018-09-873620
Defining Eosinophil Function in Adiposity and Weight Loss
Defining Eosinophil Function in Adiposity and Weight Loss
Alexander J. Knights, Emily J. Vohralik, Kyle L. Hoehn, Merlin Crossley, Kate G. R. Quinlan
BioEssays  ·  22 Aug 2018  ·  doi:10.1002/bies.201800098
Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding
Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding
Gabriella E. Martyn, Beeke Wienert, Lu Yang, Manan Shah, Laura J. Norton, …, Yukio Nakamura, Richard C. M. Pearson, Alister P. W. Funnell, Kate G. R. Quinlan, Merlin Crossley
Nature Genetics  ·  01 Apr 2018  ·  doi:10.1038/s41588-018-0085-0

2017

Genome Editing of Erythroid Cell Culture Model Systems
Genome Editing of Erythroid Cell Culture Model Systems
Jinfen J. Yik, Merlin Crossley, Kate G. R. Quinlan
Erythropoiesis  ·  27 Oct 2017  ·  doi:10.1007/978-1-4939-7428-3_15
Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic
Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic
Dianne Nicol, Lisa Eckstein, Michael Morrison, Jacob S. Sherkow, Margaret Otlowski, …, David A. Mackey, Ainsley J. Newson, Jane Nielsen, Jennifer K. Wagner, Rebekah E. McWhirter
Genome Medicine  ·  25 Sep 2017  ·  doi:10.1186/s13073-017-0475-4
KLF1 drives the expression of fetal hemoglobin in British HPFH
KLF1 drives the expression of fetal hemoglobin in British HPFH
Beeke Wienert, Gabriella E. Martyn, Ryo Kurita, Yukio Nakamura, Kate G. R. Quinlan, Merlin Crossley
Blood  ·  10 Aug 2017  ·  doi:10.1182/blood-2017-02-767400
Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch
Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch
Laura J. Norton, Samantha Hallal, Elizabeth S. Stout, Alister P. W. Funnell, Richard C. M. Pearson, Merlin Crossley, Kate G. R. Quinlan
Scientific Reports  ·  09 Jun 2017  ·  doi:10.1038/s41598-017-03289-5
Krüppel-like factors compete for promoters and enhancers to fine-tune transcription
Krüppel-like factors compete for promoters and enhancers to fine-tune transcription
Melissa D. Ilsley, Kevin R. Gillinder, Graham W. Magor, Stephen Huang, Timothy L. Bailey, Merlin Crossley, Andrew C. Perkins
Nucleic Acids Research  ·  24 May 2017  ·  doi:10.1093/nar/gkx441
The regulation of human globin promoters by CCAAT box elements and the recruitment of NF-Y
The regulation of human globin promoters by CCAAT box elements and the recruitment of NF-Y
Gabriella E. Martyn, Kate G.R. Quinlan, Merlin Crossley
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms  ·  01 May 2017  ·  doi:10.1016/j.bbagrm.2016.10.002
KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells
KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells
Laura J. Norton, Alister P. W. Funnell, Jon Burdach, Beeke Wienert, Ryo Kurita, Yukio Nakamura, Sjaak Philipsen, Richard C. M. Pearson, Kate G. R. Quinlan, Merlin Crossley
Blood Advances  ·  25 Apr 2017  ·  doi:10.1182/bloodadvances.2016002303

2016

Krüppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3)
Krüppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3)
Alexander J. Knights, Jinfen J. Yik, Hanapi Mat Jusoh, Laura J. Norton, Alister P.W. Funnell, Richard C.M. Pearson, Kim S. Bell-Anderson, Merlin Crossley, Kate G.R. Quinlan
Journal of Biological Chemistry  ·  01 Jul 2016  ·  doi:10.1074/jbc.M116.715748
Erratum to: Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor
Erratum to: Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor
Ka Sin Mak, Jon Burdach, Laura J. Norton, Richard CM Pearson, Merlin Crossley, Alister PW Funnell
Genome Biology  ·  03 Jun 2016  ·  doi:10.1186/s13059-016-0977-1
Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans
Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans
Slavica Berber, Mallory Wood, Estelle Llamosas, Priya Thaivalappil, Karen Lee, …, Yee Lian Chew, Aaron Rhodes, Duygu Yucel, Merlin Crossley, Hannah R Nicholas
Scientific Reports  ·  21 Jan 2016  ·  doi:10.1038/srep19582
Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin
Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin
Takeshi Masuda, Xin Wang, Manami Maeda, Matthew C. Canver, Falak Sher, …, Merlin Crossley, Daniel E. Bauer, Stuart H. Orkin, Peter V. Kharchenko, Takahiro Maeda
Science  ·  15 Jan 2016  ·  doi:10.1126/science.aad3312

2015

Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain
Directing an artificial zinc finger protein to new targets by fusion to a non-DNA-binding domain
Wooi F. Lim, Jon Burdach, Alister P.W. Funnell, Richard C.M. Pearson, Kate G.R. Quinlan, Merlin Crossley
Nucleic Acids Research  ·  15 Dec 2015  ·  doi:10.1093/nar/gkv1380
Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin
Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin
Beeke Wienert, Alister P. W. Funnell, Laura J. Norton, Richard C. M. Pearson, Lorna E. Wilkinson-White, …, Jim Vadolas, Matthew H. Porteus, Jacqueline M. Matthews, Kate G. R. Quinlan, Merlin Crossley
Nature Communications  ·  14 May 2015  ·  doi:10.1038/ncomms8085
Phosphorylation of Krüppel-like Factor 3 (KLF3/BKLF) and C-terminal Binding Protein 2 (CtBP2) by Homeodomain-interacting Protein Kinase 2 (HIPK2) Modulates KLF3 DNA Binding and Activity
Phosphorylation of Krüppel-like Factor 3 (KLF3/BKLF) and C-terminal Binding Protein 2 (CtBP2) by Homeodomain-interacting Protein Kinase 2 (HIPK2) Modulates KLF3 DNA Binding and Activity
Vitri Dewi, Alister Kwok, Stella Lee, Ming Min Lee, Yee Mun Tan, …, Kate G.R. Quinlan, Stuart J. Cordwell, Alister P.W. Funnell, Richard C.M. Pearson, Merlin Crossley
Journal of Biological Chemistry  ·  01 Mar 2015  ·  doi:10.1074/jbc.M115.638338

2014

The transcriptional repressor CTBP-1 functions in the nervous system of Caenorhabditis elegans to regulate lifespan
The transcriptional repressor CTBP-1 functions in the nervous system of Caenorhabditis elegans to regulate lifespan
Anna Reid, Duygu Yücel, Mallory Wood, Estelle Llamosas, Sashi Kant, Merlin Crossley, Hannah Nicholas
Experimental Gerontology  ·  01 Dec 2014  ·  doi:10.1016/j.exger.2014.09.022
Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways
Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways
Benoit Ballester, Alejandra Medina-Rivera, Dominic Schmidt, Mar Gonzàlez-Porta, Matthew Carlucci, …, Merlin Crossley, John C Marioni, Duncan T Odom, Paul Flicek, Michael D Wilson
eLife  ·  03 Oct 2014  ·  doi:10.7554/eLife.02626
The Identification and Structure of an N-Terminal PR Domain Show that FOG1 Is a Member of the PRDM Family of Proteins
The Identification and Structure of an N-Terminal PR Domain Show that FOG1 Is a Member of the PRDM Family of Proteins
Molly K. Clifton, Belinda J. Westman, Sock Yue Thong, Mitchell R. O’Connell, Michael W. Webster, Nicholas E. Shepherd, Kate G. Quinlan, Merlin Crossley, Gerd A. Blobel, Joel P. Mackay
PLoS ONE  ·  27 Aug 2014  ·  doi:10.1371/journal.pone.0106011
SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans
SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans
Duygu Yücel, Matthew Hoe, Estelle Llamosas, Sashi Kant, Callum Jamieson, Pamela A. Young, Merlin Crossley, Hannah R. Nicholas
Developmental Biology  ·  01 Aug 2014  ·  doi:10.1016/j.ydbio.2014.05.018
Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells
Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells
Alister PW Funnell, Douglas Vernimmen, Wooi F Lim, Ka Sin Mak, Beeke Wienert, …, Kate GR Quinlan, Douglas R Higgs, Emma Whitelaw, Richard CM Pearson, Merlin Crossley
BMC Molecular Biology  ·  16 May 2014  ·  doi:10.1186/1471-2199-15-8
Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor
Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor
Ka Sin Mak, Jon Burdach, Laura J Norton, Richard CM Pearson, Merlin Crossley, Alister PW Funnell
Genome Biology  ·  01 Apr 2014  ·  doi:10.1186/gb-2014-15-4-r58
Hemophilia B Leyden and once mysterious cis-regulatory mutations
Hemophilia B Leyden and once mysterious cis-regulatory mutations
Alister P.W. Funnell, Merlin Crossley
Trends in Genetics  ·  01 Jan 2014  ·  doi:10.1016/j.tig.2013.09.007

2013

Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor
Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor
J. Burdach, A. P. W. Funnell, K. S. Mak, C. M. Artuz, B. Wienert, W. F. Lim, L. Y. Tan, R. C. M. Pearson, M. Crossley
Nucleic Acids Research  ·  07 Oct 2013  ·  doi:10.1093/nar/gkt895
Homeodomain interacting protein kinase (HPK‐1) is required in the soma for robust germline proliferation in <i>C. elegans</i>
Homeodomain interacting protein kinase (HPK‐1) is required in the soma for robust germline proliferation in C. elegans
Slavica Berber, Estelle Llamosas, Priya Thaivalappil, Peter R. Boag, Merlin Crossley, Hannah R. Nicholas
Developmental Dynamics  ·  02 Sep 2013  ·  doi:10.1002/dvdy.24023
Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides?
Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides?
Joel P. Mackay, David J. Segal, Merlin Crossley
Trends in Biochemical Sciences  ·  01 Sep 2013  ·  doi:10.1016/j.tibs.2013.06.005
Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing
Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing
Alister P. W. Funnell, Ka Sin Mak, Natalie A. Twine, Gregory J. Pelka, Laura J. Norton, …, Stuart T. Fraser, Andrew C. Perkins, Patrick P. Tam, Richard C. M. Pearson, Merlin Crossley
Molecular and Cellular Biology  ·  01 Aug 2013  ·  doi:10.1128/MCB.00074-13
Loss of Krüppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2)
Loss of Krüppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2)
Kim S. Bell-Anderson, Alister P. Funnell, Helen Williams, Hanapi Mat Jusoh, Tiffany Scully, …, Hannah R. Nicholas, Amanda Sainsbury, Nigel Turner, Richard C. Pearson, Merlin Crossley
Diabetes  ·  17 Jul 2013  ·  doi:10.2337/db12-1745
ENU-induced Mutation in the DNA-binding Domain of KLF3 Reveals Important Roles for KLF3 in Cardiovascular Development and Function in Mice
ENU-induced Mutation in the DNA-binding Domain of KLF3 Reveals Important Roles for KLF3 in Cardiovascular Development and Function in Mice
Lois Kelsey, Ann M. Flenniken, Dawei Qu, Alister P. W. Funnell, Richard Pearson, …, Lucy Osborne, Janet Rossant, Merlin Crossley, Benoit Bruneau, S. Lee Adamson
PLoS Genetics  ·  11 Jul 2013  ·  doi:10.1371/journal.pgen.1003612
New Insights into DNA Recognition by Zinc Fingers Revealed by Structural Analysis of the Oncoprotein ZNF217
New Insights into DNA Recognition by Zinc Fingers Revealed by Structural Analysis of the Oncoprotein ZNF217
Marylène Vandevenne, David A. Jacques, Crisbel Artuz, Cuong Dinh Nguyen, Ann H.Y. Kwan, David J. Segal, Jacqueline M. Matthews, Merlin Crossley, J.Mitchell Guss, Joel P. Mackay
Journal of Biological Chemistry  ·  01 Apr 2013  ·  doi:10.1074/jbc.M112.441451
A CpG Mutational Hotspot in a ONECUT Binding Site Accounts for the Prevalent Variant of Hemophilia B Leyden
A CpG Mutational Hotspot in a ONECUT Binding Site Accounts for the Prevalent Variant of Hemophilia B Leyden
Alister P.W. Funnell, Michael D. Wilson, Benoit Ballester, Ka Sin Mak, Jon Burdach, …, Frederic P. Lemaigre, Kathryn M. Stowell, Duncan T. Odom, Paul Flicek, Merlin Crossley
The American Journal of Human Genetics  ·  01 Mar 2013  ·  doi:10.1016/j.ajhg.2013.02.003

2012

The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation <i>In Vivo</i>
The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo
Alister P. W. Funnell, Laura J. Norton, Ka Sin Mak, Jon Burdach, Crisbel M. Artuz, …, Stuart H. Orkin, Stuart T. Fraser, Andrew C. Perkins, Richard C. M. Pearson, Merlin Crossley
Molecular and Cellular Biology  ·  01 Aug 2012  ·  doi:10.1128/MCB.00173-12
Controlling the size of lipid droplets: lipid and protein factors
Controlling the size of lipid droplets: lipid and protein factors
Hongyuan Yang, Anne Galea, Vladimir Sytnyk, Merlin Crossley
Current Opinion in Cell Biology  ·  01 Aug 2012  ·  doi:10.1016/j.ceb.2012.05.012
Two-timing zinc finger transcription factors liaising with RNA
Two-timing zinc finger transcription factors liaising with RNA
Jon Burdach, Mitchell R. O’Connell, Joel P. Mackay, Merlin Crossley
Trends in Biochemical Sciences  ·  01 May 2012  ·  doi:10.1016/j.tibs.2012.02.001
A rapid method for assessing the RNA-binding potential of a protein
A rapid method for assessing the RNA-binding potential of a protein
K. Bendak, F.E. Loughlin, V. Cheung, M.R. O’Connell, M. Crossley, J.P. Mackay
Nucleic Acids Research  ·  03 Apr 2012  ·  doi:10.1093/nar/gks285
Homo- and Heterodimerization in Transcriptional Regulation
Homo- and Heterodimerization in Transcriptional Regulation
Alister P. W. Funnell, Merlin Crossley
Advances in Experimental Medicine and Biology  ·  01 Jan 2012  ·  doi:10.1007/978-1-4614-3229-6_7

2011

Impaired B Cell Development in the Absence of Krüppel-like Factor 3
Impaired B Cell Development in the Absence of Krüppel-like Factor 3
Thi Thanh Vu, Dominique Gatto, Vivian Turner, Alister P. W. Funnell, Ka Sin Mak, …, Fabien Agenès, Jörg Kirberg, Robert Brink, Richard C. M. Pearson, Merlin Crossley
The Journal of Immunology  ·  15 Nov 2011  ·  doi:10.4049/jimmunol.1101450
The Multi-zinc Finger Protein ZNF217 Contacts DNA through a Two-finger Domain
The Multi-zinc Finger Protein ZNF217 Contacts DNA through a Two-finger Domain
Noelia Nunez, Molly M.K. Clifton, Alister P.W. Funnell, Crisbel Artuz, Samantha Hallal, …, Marylène Vandevenne, Surya Setiyaputra, Richard C.M. Pearson, Joel P. Mackay, Merlin Crossley
Journal of Biological Chemistry  ·  01 Nov 2011  ·  doi:10.1074/jbc.M111.301234
Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1
Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1
Lorna Wilkinson-White, Roland Gamsjaeger, Siavoush Dastmalchi, Beeke Wienert, Philippa H. Stokes, Merlin Crossley, Joel P. Mackay, Jacqueline M. Matthews
Proceedings of the National Academy of Sciences  ·  15 Aug 2011  ·  doi:10.1073/pnas.1105898108
Protein–protein interactions: Analysis of a false positive GST pulldown result
Protein–protein interactions: Analysis of a false positive GST pulldown result
Sandra Wissmueller, Josep Font, Chu Wai Liew, Edward Cram, Thilo Schroeder, Jeremy Turner, Merlin Crossley, Joel P. Mackay, Jacqueline M. Matthews
Proteins: Structure, Function, and Bioinformatics  ·  02 Jun 2011  ·  doi:10.1002/prot.23068
C-terminal binding protein: A metabolic sensor implicated in regulating adipogenesis
C-terminal binding protein: A metabolic sensor implicated in regulating adipogenesis
Briony H.A. Jack, Richard C. Pearson, Merlin Crossley
The International Journal of Biochemistry & Cell Biology  ·  01 May 2011  ·  doi:10.1016/j.biocel.2011.01.017
Programming of marginal zone B-cell fate by basic Krüppel-like factor (BKLF/KLF3)
Programming of marginal zone B-cell fate by basic Krüppel-like factor (BKLF/KLF3)
Gleb Turchinovich, Thi Thanh Vu, Friederike Frommer, Jan Kranich, Sonja Schmid, …, Jürgen Bachl, Richard Pearson, Merlin Crossley, Fabien Agenès, Jörg Kirberg
Blood  ·  07 Apr 2011  ·  doi:10.1182/blood-2010-09-308742
The mammalian zinc finger transcription factor Krüppel‐like factor 3 (KLF3/BKLF)
The mammalian zinc finger transcription factor Krüppel‐like factor 3 (KLF3/BKLF)
Richard C.M. Pearson, Alister P.W. Funnell, Merlin Crossley
IUBMB Life  ·  01 Feb 2011  ·  doi:10.1002/iub.422
PU.1 and Haematopoietic Cell Fate: Dosage Matters
PU.1 and Haematopoietic Cell Fate: Dosage Matters
Ka Sin Mak, Alister P. W. Funnell, Richard C. M. Pearson, Merlin Crossley
International Journal of Cell Biology  ·  01 Jan 2011  ·  doi:10.1155/2011/808524
Cellular Reprogramming toward the Erythroid Lineage
Cellular Reprogramming toward the Erythroid Lineage
Laura J. Norton, Alister P. W. Funnell, Richard C. M. Pearson, Merlin Crossley
International Journal of Cell Biology  ·  01 Jan 2011  ·  doi:10.1155/2011/501464

2010

GATA Proteins Work Together with Friend of GATA (FOG) and C-terminal Binding Protein (CTBP) Co-regulators to Control Adipogenesis
GATA Proteins Work Together with Friend of GATA (FOG) and C-terminal Binding Protein (CTBP) Co-regulators to Control Adipogenesis
Briony H.A. Jack, Merlin Crossley
Journal of Biological Chemistry  ·  01 Oct 2010  ·  doi:10.1074/jbc.M110.141317
KLF3 Regulates Muscle-Specific Gene Expression and Synergizes with Serum Response Factor on KLF Binding Sites
KLF3 Regulates Muscle-Specific Gene Expression and Synergizes with Serum Response Factor on KLF Binding Sites
Charis L. Himeda, Jeffrey A. Ranish, Richard C. M. Pearson, Merlin Crossley, Stephen D. Hauschka
Molecular and Cellular Biology  ·  01 Jul 2010  ·  doi:10.1128/MCB.00302-10

2008

A Network of Krüppel-like Factors (Klfs)
A Network of Krüppel-like Factors (Klfs)
Sally A. Eaton, Alister P.W. Funnell, Nancy Sue, Hannah Nicholas, Richard C.M. Pearson, Merlin Crossley
Journal of Biological Chemistry  ·  01 Oct 2008  ·  doi:10.1074/jbc.M804831200
Targeted Disruption of the Basic Krüppel-Like Factor Gene (<i>Klf3</i>) Reveals a Role in Adipogenesis
Targeted Disruption of the Basic Krüppel-Like Factor Gene (Klf3) Reveals a Role in Adipogenesis
Nancy Sue, Briony H. A. Jack, Sally A. Eaton, Richard C. M. Pearson, Alister P. W. Funnell, …, Andrew Perkins, Yuko Fujiwara, Stuart H. Orkin, Kim Bell-Anderson, Merlin Crossley
Molecular and Cellular Biology  ·  01 Jun 2008  ·  doi:10.1128/MCB.01942-07
Response to Chatr-aryamontri et al.: Protein interactions: to believe or not to believe?
Response to Chatr-aryamontri et al.: Protein interactions: to believe or not to believe?
Joel P. Mackay, Margaret Sunde, Jason A. Lowry, Merlin Crossley, Jacqueline M. Matthews
Trends in Biochemical Sciences  ·  01 Jun 2008  ·  doi:10.1016/j.tibs.2008.04.003
A mechanism for Ikaros regulation of human globin gene switching
A mechanism for Ikaros regulation of human globin gene switching
Janelle R. Keys, Michael R. Tallack, Ye Zhan, Peter Papathanasiou, Christopher C. Goodnow, Karin M. Gaensler, Merlin Crossley, Job Dekker, Andrew C. Perkins
British Journal of Haematology  ·  09 Apr 2008  ·  doi:10.1111/j.1365-2141.2008.07065.x
Hls5 regulated erythroid differentiation by modulating GATA-1 activity
Hls5 regulated erythroid differentiation by modulating GATA-1 activity
Raelene Endersby, Ian J. Majewski, Louise Winteringham, Jennifer G. Beaumont, Amy Samuels, Robin Scaife, Esther Lim, Merlin Crossley, S. Peter Klinken, Jean-Philippe Lalonde
Blood  ·  15 Feb 2008  ·  doi:10.1182/blood-2007-04-085746
The Caenorhabditis elegans Protein CTBP-1 Defines a New Group of THAP Domain-Containing CtBP Corepressors
The Caenorhabditis elegans Protein CTBP-1 Defines a New Group of THAP Domain-Containing CtBP Corepressors
Hannah R. Nicholas, Jason A. Lowry, Tina Wu, Merlin Crossley
Journal of Molecular Biology  ·  01 Jan 2008  ·  doi:10.1016/j.jmb.2007.10.041
Krüppel-like transcription factors: A functional family
Krüppel-like transcription factors: A functional family
Richard Pearson, Jacqueline Fleetwood, Sally Eaton, Merlin Crossley, Shisan Bao
The International Journal of Biochemistry & Cell Biology  ·  01 Jan 2008  ·  doi:10.1016/j.biocel.2007.07.018

2007

Protein interactions: is seeing believing?
Protein interactions: is seeing believing?
J MACKAY, M SUNDE, J LOWRY, M CROSSLEY, J MATTHEWS
Trends in Biochemical Sciences  ·  01 Dec 2007  ·  doi:10.1016/j.tibs.2007.09.006
Amplification of zinc finger gene 217 (ZNF217) and cancer: When good fingers go bad
Amplification of zinc finger gene 217 (ZNF217) and cancer: When good fingers go bad
K QUINLAN, A VERGER, P YASWEN, M CROSSLEY
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer  ·  01 Jun 2007  ·  doi:10.1016/j.bbcan.2007.05.001
A Novel Corepressor, BCoR-L1, Represses Transcription through an Interaction with CtBP
A Novel Corepressor, BCoR-L1, Represses Transcription through an Interaction with CtBP
Julia K. Pagan, Jeremy Arnold, Kim J. Hanchard, Raman Kumar, Tiziana Bruno, …, Merlin Crossley, Maurizio Fanciulli, Georgia Chenevix-Trench, David B. Young, Kum Kum Khanna
Journal of Biological Chemistry  ·  01 May 2007  ·  doi:10.1074/jbc.M700246200
Erythroid Krüppel-Like Factor Directly Activates the Basic Krüppel-Like Factor Gene in Erythroid Cells
Erythroid Krüppel-Like Factor Directly Activates the Basic Krüppel-Like Factor Gene in Erythroid Cells
Alister P. W. Funnell, Christopher A. Maloney, Lucinda J. Thompson, Janelle Keys, Michael Tallack, Andrew C. Perkins, Merlin Crossley
Molecular and Cellular Biology  ·  01 Apr 2007  ·  doi:10.1128/MCB.01658-06
Sticky fingers: zinc-fingers as protein-recognition motifs
Sticky fingers: zinc-fingers as protein-recognition motifs
R GAMSJAEGER, C LIEW, F LOUGHLIN, M CROSSLEY, J MACKAY
Trends in Biochemical Sciences  ·  01 Feb 2007  ·  doi:10.1016/j.tibs.2006.12.007
Solution Structure of the THAP Domain from Caenorhabditis elegans C-terminal Binding Protein (CtBP)
Solution Structure of the THAP Domain from Caenorhabditis elegans C-terminal Binding Protein (CtBP)
Chu Kong Liew, Merlin Crossley, Joel P. Mackay, Hannah R. Nicholas
Journal of Molecular Biology  ·  01 Feb 2007  ·  doi:10.1016/j.jmb.2006.11.058

2006

Specific Recognition of ZNF217 and Other Zinc Finger Proteins at a Surface Groove of C-Terminal Binding Proteins
Specific Recognition of ZNF217 and Other Zinc Finger Proteins at a Surface Groove of C-Terminal Binding Proteins
Kate G. R. Quinlan, Marco Nardini, Alexis Verger, Pierangelo Francescato, Paul Yaswen, Daniela Corda, Martino Bolognesi, Merlin Crossley
Molecular and Cellular Biology  ·  01 Nov 2006  ·  doi:10.1128/MCB.00680-06
Role of the C-Terminal Binding Protein PXDLS Motif Binding Cleft in Protein Interactions and Transcriptional Repression
Role of the C-Terminal Binding Protein PXDLS Motif Binding Cleft in Protein Interactions and Transcriptional Repression
Kate G. R. Quinlan, Alexis Verger, Alister Kwok, Stella H. Y. Lee, José Perdomo, Marco Nardini, Martino Bolognesi, Merlin Crossley
Molecular and Cellular Biology  ·  01 Nov 2006  ·  doi:10.1128/MCB.00445-06
Molecular Analysis of the Interaction between the Hematopoietic Master Transcription Factors GATA-1 and PU.1
Molecular Analysis of the Interaction between the Hematopoietic Master Transcription Factors GATA-1 and PU.1
Chu Wai Liew, Kasper D. Rand, Raina J.Y. Simpson, Wendy W. Yung, Robyn E. Mansfield, Merlin Crossley, Mette Proetorius-Ibba, Claus Nerlov, Flemming M. Poulsen, Joel P. Mackay
Journal of Biological Chemistry  ·  01 Sep 2006  ·  doi:10.1074/jbc.M602830200
Mechanisms Directing the Nuclear Localization of the CtBP Family Proteins
Mechanisms Directing the Nuclear Localization of the CtBP Family Proteins
Alexis Verger, Kate G. R. Quinlan, Linda A. Crofts, Stefania Spanò, Daniela Corda, Eleanor P. W. Kable, Filip Braet, Merlin Crossley
Molecular and Cellular Biology  ·  01 Jul 2006  ·  doi:10.1128/MCB.02402-05
A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP
A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP
Nicolas Stankovic‐Valentin, Alexis Verger, Sophie Deltour‐Balerdi, Kate G. R. Quinlan, Merlin Crossley, Dominique Leprince
The FEBS Journal  ·  07 Jun 2006  ·  doi:10.1111/j.1742-4658.2006.05301.x
Human KLF17 is a new member of the Sp/KLF family of transcription factors
Human KLF17 is a new member of the Sp/KLF family of transcription factors
Jane van Vliet, Linda A. Crofts, Kate G.R. Quinlan, Robert Czolij, Andrew C. Perkins, Merlin Crossley
Genomics  ·  01 Apr 2006  ·  doi:10.1016/j.ygeno.2005.12.011

2005

Role for SUMO Modification in Facilitating Transcriptional Repression by BKLF
Role for SUMO Modification in Facilitating Transcriptional Repression by BKLF
José Perdomo, Alexis Verger, Jeremy Turner, Merlin Crossley
Molecular and Cellular Biology  ·  01 Feb 2005  ·  doi:10.1128/MCB.25.4.1549-1559.2005
Assessment of the Robustness of a Serendipitous Zinc Binding Fold: Mutagenesis and Protein Grafting
Assessment of the Robustness of a Serendipitous Zinc Binding Fold: Mutagenesis and Protein Grafting
Belinda K. Sharpe, Chu Kong Liew, Ann H. Kwan, Jackie A. Wilce, Merlin Crossley, Jacqueline M. Matthews, Joel P. Mackay
Structure  ·  01 Feb 2005  ·  doi:10.1016/j.str.2004.12.007
Zinc fingers as protein recognition motifs: Structural basis for the GATA-1/Friend of GATA interaction
Zinc fingers as protein recognition motifs: Structural basis for the GATA-1/Friend of GATA interaction
Chu Kong Liew, Raina J. Y. Simpson, Ann H. Y. Kwan, Linda A. Crofts, Fionna E. Loughlin, Jacqueline M. Matthews, Merlin Crossley, Joel P. Mackay
Proceedings of the National Academy of Sciences  ·  11 Jan 2005  ·  doi:10.1073/pnas.0407511102

2004

KAI1 promoter activity is dependent on p53, junB and AP2: evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells
KAI1 promoter activity is dependent on p53, junB and AP2: evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells
Alexandra Marreiros, Kip Dudgeon, Vinh Dao, Marc-Oliver Grimm, Robert Czolij, Merlin Crossley, Paul Jackson
Oncogene  ·  06 Dec 2004  ·  doi:10.1038/sj.onc.1208216
A Classic Zinc Finger from Friend of GATA Mediates an Interaction with the Coiled-coil of Transforming Acidic Coiled-coil 3
A Classic Zinc Finger from Friend of GATA Mediates an Interaction with the Coiled-coil of Transforming Acidic Coiled-coil 3
Raina J.Y. Simpson, Stella Hoi Yi Lee, Natalie Bartle, Eleanor Y. Sum, Jane E. Visvader, Jacqueline M. Matthews, Joel P. Mackay, Merlin Crossley
Journal of Biological Chemistry  ·  01 Sep 2004  ·  doi:10.1074/jbc.M404130200
DNA damage repair and transcription
DNA damage repair and transcription
A. Verger, M. Crossley
Cellular and Molecular Life Sciences  ·  01 Aug 2004  ·  doi:10.1007/s00018-004-4176-y
Protein-Protein Interaction between Fli-1 and GATA-1 Mediates Synergistic Expression of Megakaryocyte-Specific Genes through Cooperative DNA Binding
Protein-Protein Interaction between Fli-1 and GATA-1 Mediates Synergistic Expression of Megakaryocyte-Specific Genes through Cooperative DNA Binding
Molecular and Cellular Biology  ·  01 Jun 2004  ·  doi:10.1128/MCB.24.11.5088.2004
Activation and Repression of Interleukin-12 p40 Transcription by Erythroid Kruppel-like Factor in Macrophages
Activation and Repression of Interleukin-12 p40 Transcription by Erythroid Kruppel-like Factor in Macrophages
Qi Luo, Xiaojing Ma, Sharon M. Wahl, James J. Bieker, Merlin Crossley, Luis J. Montaner
Journal of Biological Chemistry  ·  01 Apr 2004  ·  doi:10.1074/jbc.M400320200

2003

Mutations ofZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot
Mutations ofZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot
Antonio Pizzuti, Anna Sarkozy, Anthea L. Newton, Emanuela Conti, Elisabetta Flex, …, Debora Gianni, Caterina Tandoi, Bruno Marino, Merlin Crossley, Bruno Dallapiccola
Human Mutation  ·  17 Nov 2003  ·  doi:10.1002/humu.10308
The C-terminal Domain of Eos Forms a High Order Complex in Solution
The C-terminal Domain of Eos Forms a High Order Complex in Solution
Belinda J. Westman, José Perdomo, Margaret Sunde, Merlin Crossley, Joel P. Mackay
Journal of Biological Chemistry  ·  01 Oct 2003  ·  doi:10.1074/jbc.M306817200
Mutations ofZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot
Mutations ofZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot
Antonio Pizzuti, Anna Sarkozy, Anthea L. Newton, Emanuela Conti, Elisabetta Flex, …, Debora Gianni, Caterina Tandoi, Bruno Marino, Merlin Crossley, Bruno Dallapiccola
Human Mutation  ·  24 Sep 2003  ·  doi:10.1002/humu.10261
Engineering a Protein Scaffold from a PHD Finger
Engineering a Protein Scaffold from a PHD Finger
Ann H.Y. Kwan, David A. Gell, Alexis Verger, Merlin Crossley, Jacqueline M. Matthews, Joel P. Mackay
Structure  ·  01 Jul 2003  ·  doi:10.1016/S0969-2126(03)00122-9
CCHX Zinc Finger Derivatives Retain the Ability to Bind Zn(II) and Mediate Protein-DNA Interactions
CCHX Zinc Finger Derivatives Retain the Ability to Bind Zn(II) and Mediate Protein-DNA Interactions
Raina J.Y. Simpson, Edward D. Cram, Robert Czolij, Jacqueline M. Matthews, Merlin Crossley, Joel P. Mackay
Journal of Biological Chemistry  ·  01 Jul 2003  ·  doi:10.1074/jbc.M211146200
Protein-Protein Interaction between Fli-1 and GATA-1 Mediates Synergistic Expression of Megakaryocyte-Specific Genes through Cooperative DNA Binding
Protein-Protein Interaction between Fli-1 and GATA-1 Mediates Synergistic Expression of Megakaryocyte-Specific Genes through Cooperative DNA Binding
Michael Eisbacher, Melissa L. Holmes, Anthea Newton, Philip J. Hogg, Levon M. Khachigian, Merlin Crossley, Beng H. Chong
Molecular and Cellular Biology  ·  01 May 2003  ·  doi:10.1128/MCB.23.10.3427-3441.2003
The LIM Protein FHL3 Binds Basic Krüppel-like Factor/Krüppel-like Factor 3 and Its Co-repressor C-terminal-binding Protein 2
The LIM Protein FHL3 Binds Basic Krüppel-like Factor/Krüppel-like Factor 3 and Its Co-repressor C-terminal-binding Protein 2
Jeremy Turner, Hannah Nicholas, David Bishop, Jacqueline M. Matthews, Merlin Crossley
Journal of Biological Chemistry  ·  01 Apr 2003  ·  doi:10.1074/jbc.M300587200
Modification with SUMO
Modification with SUMO
Alexis Verger, José Perdomo, Merlin Crossley
EMBO reports  ·  01 Feb 2003  ·  doi:10.1038/sj.embor.embor738
citation image
[no title info]
Merlin Crossley
Genome Biology  ·  01 Jan 2003  ·  doi:10.1186/gb-2003-4-5-320
Identification of regulatory regions within the KAI1 promoter: a role for binding of AP1, AP2 and p53
Identification of regulatory regions within the KAI1 promoter: a role for binding of AP1, AP2 and p53
Alexandra Marreiros, Robert Czolij, Gina Yardley, Merlin Crossley, Paul Jackson
Gene  ·  01 Jan 2003  ·  doi:10.1016/S0378-1119(02)01101-0

2002

The Ikaros family protein Eos associates with C‐terminal‐binding protein corepressors
The Ikaros family protein Eos associates with C‐terminal‐binding protein corepressors
José Perdomo, Merlin Crossley
European Journal of Biochemistry  ·  23 Nov 2002  ·  doi:10.1046/j.1432-1033.2002.03313.x
Characterization of the Conserved Interaction between GATA and FOG Family Proteins
Characterization of the Conserved Interaction between GATA and FOG Family Proteins
Kasper Kowalski, Chu Kong Liew, Jacqueline M. Matthews, David A. Gell, Merlin Crossley, Joel P. Mackay
Journal of Biological Chemistry  ·  01 Sep 2002  ·  doi:10.1074/jbc.M204663200
A New Zinc Binding Fold Underlines the Versatility of Zinc Binding Modules in Protein Evolution
A New Zinc Binding Fold Underlines the Versatility of Zinc Binding Modules in Protein Evolution
Belinda K. Sharpe, Jacqueline M. Matthews, Ann H.Y. Kwan, Anthea Newton, David A. Gell, Merlin Crossley, Joel P. Mackay
Structure  ·  01 May 2002  ·  doi:10.1016/S0969-2126(02)00757-8

2001

X-linked thrombocytopenia caused by a novel mutation ofGATA-1
X-linked thrombocytopenia caused by a novel mutation ofGATA-1
Michele G. Mehaffey, Anthea L. Newton, Manish J. Gandhi, Merlin Crossley, Jonathan G. Drachman
Blood  ·  01 Nov 2001  ·  doi:10.1182/blood.V98.9.2681
The Role of the Coiled-Coil Motif in Interactions Mediated by TPD52
The Role of the Coiled-Coil Motif in Interactions Mediated by TPD52
Pavani Sathasivam, Angela M. Bailey, Merlin Crossley, Jennifer A. Byrne
Biochemical and Biophysical Research Communications  ·  01 Oct 2001  ·  doi:10.1006/bbrc.2001.5721
The N-terminal Zinc Finger of the Erythroid Transcription Factor GATA-1 Binds GATC Motifs in DNA
The N-terminal Zinc Finger of the Erythroid Transcription Factor GATA-1 Binds GATC Motifs in DNA
Anthea Newton, Joel Mackay, Merlin Crossley
Journal of Biological Chemistry  ·  01 Sep 2001  ·  doi:10.1074/jbc.M106256200
The CtBP family: enigmatic and enzymatic transcriptional co‐repressors
The CtBP family: enigmatic and enzymatic transcriptional co‐repressors
Jeremy Turner, Merlin Crossley
BioEssays  ·  25 Jul 2001  ·  doi:10.1002/bies.1097
Induction of AP-2α Expression by Adenoviral Infection Involves Inactivation of the AP-2rep Transcriptional Corepressor CtBP1
Induction of AP-2α Expression by Adenoviral Infection Involves Inactivation of the AP-2rep Transcriptional Corepressor CtBP1
Marion Schuierer, Kristina Hilger-Eversheim, Thomas Dobner, Anja-Katrin Bosserhoff, Markus Moser, Jeremy Turner, Merlin Crossley, Reinhard Buettner
Journal of Biological Chemistry  ·  01 Jul 2001  ·  doi:10.1074/jbc.M100070200
Evi-1 Transforming and Repressor Activities Are Mediated by CtBP Co-repressor Proteins
Evi-1 Transforming and Repressor Activities Are Mediated by CtBP Co-repressor Proteins
Susan Palmer, Jean-Paul Brouillet, Anna Kilbey, Ruth Fulton, Mark Walker, Merlin Crossley, Chris Bartholomew
Journal of Biological Chemistry  ·  01 Jul 2001  ·  doi:10.1074/jbc.M102343200

2000

Eos and Pegasus, Two Members of the Ikaros Family of Proteins with Distinct DNA Binding Activities
Eos and Pegasus, Two Members of the Ikaros Family of Proteins with Distinct DNA Binding Activities
José Perdomo, Melissa Holmes, Beng Chong, Merlin Crossley
Journal of Biological Chemistry  ·  01 Dec 2000  ·  doi:10.1074/jbc.M005457200
Solution Structures of Two CCHC Zinc Fingers from the FOG Family Protein U-Shaped that Mediate Protein–Protein Interactions
Solution Structures of Two CCHC Zinc Fingers from the FOG Family Protein U-Shaped that Mediate Protein–Protein Interactions
Chu Kong Liew, Kasper Kowalski, Archa H Fox, Anthea Newton, Belinda K Sharpe, Merlin Crossley, Joel P Mackay
Structure  ·  01 Nov 2000  ·  doi:10.1016/S0969-2126(00)00527-X
The Transactivation Domain within Cysteine/Histidine-rich Region 1 of CBP Comprises Two Novel Zinc-binding Modules
The Transactivation Domain within Cysteine/Histidine-rich Region 1 of CBP Comprises Two Novel Zinc-binding Modules
Anthea L. Newton, Belinda K. Sharpe, Ann Kwan, Joel P. Mackay, Merlin Crossley
Journal of Biological Chemistry  ·  01 May 2000  ·  doi:10.1074/jbc.M910396199
A class of zinc fingers involved in protein–protein interactions
A class of zinc fingers involved in protein–protein interactions
Jacqueline M. Matthews, Kasper Kowalski, Chu Kong Liew, Belinda K. Sharpe, Archa H. Fox, Merlin Crossley, Joel P. Mackay
European Journal of Biochemistry  ·  01 Feb 2000  ·  doi:10.1046/j.1432-1327.2000.01095.x

1999

Basic Krüppel-like factor functions within a network of interacting haematopoietic transcription factors
Basic Krüppel-like factor functions within a network of interacting haematopoietic transcription factors
Jeremy Turner, Merlin Crossley
The International Journal of Biochemistry & Cell Biology  ·  01 Oct 1999  ·  doi:10.1016/S1357-2725(99)00067-9
hFOG-2, a Novel Zinc Finger Protein, Binds the Co-repressor mCtBP2 and Modulates GATA-mediated Activation
hFOG-2, a Novel Zinc Finger Protein, Binds the Co-repressor mCtBP2 and Modulates GATA-mediated Activation
Melissa Holmes, Jeremy Turner, Archa Fox, Orin Chisholm, Merlin Crossley, Beng Chong
Journal of Biological Chemistry  ·  01 Aug 1999  ·  doi:10.1074/jbc.274.33.23491
Mammalian Krüppel-like transcription factors: more than just a pretty finger
Mammalian Krüppel-like transcription factors: more than just a pretty finger
Jeremy Turner, Merlin Crossley
Trends in Biochemical Sciences  ·  01 Jun 1999  ·  doi:10.1016/S0968-0004(99)01406-1
Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers
Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers
Archa H. Fox, Chu Liew, Melissa Holmes, Kasper Kowalski, Joel Mackay, Merlin Crossley
The EMBO Journal  ·  17 May 1999  ·  doi:10.1093/emboj/18.10.2812
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[no title info]
K. Kowalski, R. Czolij, G.F. King, M. Crossley, J.P. Mackay
Journal of Biomolecular NMR  ·  01 Jan 1999  ·  doi:10.1023/A:1008309602929

1998

Key Residues Characteristic of GATA N-fingers Are Recognized By FOG
Key Residues Characteristic of GATA N-fingers Are Recognized By FOG
Archa H. Fox, Kasper Kowalski, Glenn F. King, Joel P. Mackay, Merlin Crossley
Journal of Biological Chemistry  ·  01 Dec 1998  ·  doi:10.1074/jbc.273.50.33595
Involvement of the N-finger in the Self-association of GATA-1
Involvement of the N-finger in the Self-association of GATA-1
Joel P. Mackay, Kasper Kowalski, Archa H. Fox, Robert Czolij, Glenn F. King, Merlin Crossley
Journal of Biological Chemistry  ·  01 Nov 1998  ·  doi:10.1074/jbc.273.46.30560
Transcription Factor Erythroid Krüppel-like Factor (ELKF) Is Essential for the Erythropoietin-induced Hemoglobin Production but Not for Proliferation, Viability, or Morphological Maturation
Transcription Factor Erythroid Krüppel-like Factor (ELKF) Is Essential for the Erythropoietin-induced Hemoglobin Production but Not for Proliferation, Viability, or Morphological Maturation
Angelo Spadaccini, Peta A. Tilbrook, Mohinder K. Sarna, Merlin Crossley, James J. Bieker, S. Peter Klinken
Journal of Biological Chemistry  ·  01 Sep 1998  ·  doi:10.1074/jbc.273.37.23793
Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators
Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators
J. Turner
The EMBO Journal  ·  01 Sep 1998  ·  doi:10.1093/emboj/17.17.5129
Expression of the parathyroid Ca(2+)-sensing receptor in cytotrophoblasts from human term placenta
Expression of the parathyroid Ca(2+)-sensing receptor in cytotrophoblasts from human term placenta
RA Bradbury, KL Sunn, M Crossley, M Bai, EM Brown, L Delbridge, AD Conigrave
Journal of Endocrinology  ·  01 Mar 1998  ·  doi:10.1677/joe.0.1560425
Zinc fingers are sticking together
Zinc fingers are sticking together
Joel P. Mackay, Merlin Crossley
Trends in Biochemical Sciences  ·  01 Jan 1998  ·  doi:10.1016/S0968-0004(97)01168-7

1997

FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation
FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation
Alice P Tsang, Jane E Visvader, C.Alexander Turner, Yuko Fujiwara, Channing Yu, Mitchell J Weiss, Merlin Crossley, Stuart H Orkin
Cell  ·  01 Jul 1997  ·  doi:10.1016/S0092-8674(00)80318-9

1993

Regulation of the β-globin locus
Regulation of the β-globin locus
Merlin Crossley, Stuart H. Orkin
Current Opinion in Genetics & Development  ·  01 Jan 1993  ·  doi:10.1016/0959-437X(93)90028-N

1992

Recovery from Hemophilia B Leyden: An Androgen-Responsive Element in the Factor IX Promoter
Recovery from Hemophilia B Leyden: An Androgen-Responsive Element in the Factor IX Promoter
Merlin Crossley, Michael Ludwig, Kathryn M. Stowell, Piet De Vos, Klaus Olek, George G. Brownlee
Science  ·  17 Jul 1992  ·  doi:10.1126/science.1631558

1990

A less severe form of Haemophilia B Leyden
A less severe form of Haemophilia B Leyden
M. Crossley, P. R. Winship, D. E.G. Austen, C. R. Rizza, G. G. Brownlee
Nucleic Acids Research  ·  11 Aug 1990  ·  doi:10.1093/nar/18.15.4633
Comparative sequence analysis of mammalian factor IX promoters
Comparative sequence analysis of mammalian factor IX promoters
C.-P. Pang, M. Crossley, G. Kent, G.G. Brownlee
Nucleic Acids Research  ·  01 Jan 1990  ·  doi:10.1093/nar/18.22.6731

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